How do essential cellular mechanisms evolve?
Early studies emphasized the universal principles shared across life’s domains, but recent research is revealing striking species-specific differences in executing fundamental functions. Genomes are organized into distinct chromosome sets, replicated, segregated, and repaired by unique protein assemblies. The origins of this variability remain a mystery.
We recently showed that genome maintenance mechanisms can rapidly rewire when perturbed, demonstrating how evolutionary cell biology can be studied experimentally.
Our lab uses S. cerevisiae as a model eukaryote to investigate the molecular mechanisms that enable cells to adapt to genome maintenance challenges.
We take a multidisciplinary approach, integrating techniques and concepts across biological scales, from molecular and cellular biology to genomics, biophysics, evolutionary, and population genetics.
Open Science
We do our best to promote Open Science. Below are a number of initiatives and associations we support:
